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Targeted Allele Detail
Symbol: Tcra-Jtm1Tgi
Name: T cell receptor alpha, joining region; targeted mutation 1, Masaru Taniguchi
MGI ID: MGI:2180736
Synonyms: JA18-, Ja180, Jalpha18-, Jalpha18-, Jalpha18KO, Jalpha18-KO, Jalpha281-, Jalpha281KO, Jalpha281 KO, NK T KO, NKT-KO, TCR Jalpha18-, Valpha14 NKT-KO
Gene: Tcra-J  Location: unknown  Genetic Position: Chr14, Syntenic
Il17rbtm1Hwata/Il17rbtm1Hwata and Tcra-Jtm1Tgi/Tcra-Jtm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:76989
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire sequence of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. An absence of transcipt in homozygous mutant mice was determined by RNAse protection. (J:76989)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcra-J Mutation:  0 strains or lines available
Original:  J:76989 Cui J, et al., Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science. 1997 Nov 28;278(5343):1623-6
All:  293 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory