Zic3^tm1Bca
Targeted Allele Detail

Summary

• Symbol: Zic3^tm1Bca
• Name: zinc finger protein of the cerebellum 3; targeted mutation 1, Brett Casey
• MGI ID: MGI:2180720
• Synonyms: Zic3-, Zic3-lacZ, Zic3^null
• Gene: Zic3 Location: ChrX:57075988-57081990 bp, + strand Genetic Position: ChrX, 32.56 cM
• Alliance: Zic3^tm1Bca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75951
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of the gene was replaced with an IRES-lacZ reporter gene. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. (J:75951)

Disease models

Expression

In Mice Carrying this Mutation:	53 assay results
In Structures Affected by this Mutation:	39 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zic3 Mutation: 37 strains or lines available

References

• Original: J:75951 Purandare SM, et al., A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice. Development. 2002 May;129(9):2293-302
• All: 8 reference(s)