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Pik3cbtm1Nbm
Targeted Allele Detail
Nomenclature
Symbol: Pik3cbtm1Nbm
Name: phosphatidylinositol 3-kinase, catalytic, beta polypeptide; targeted mutation 1, Robert L Nussbaum
MGI ID: MGI:2180703
Synonyms: p110beta-, Pik3cbdel
Gene: Pik3cb  Location: Chr9:99036654-99140621 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Phase contrast microscopy of blastobysts flushed at day 3.5 d.p.c.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75617
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo exons spanning nucleotides 2943-3180 were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event deletes 79 amino acids from position 982-1060 forming 28% of the phosphoinositol 3-kinase catalytic domain. (J:75617)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:  83 strains or lines available
References
Original:  J:75617 Bi L, et al., Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome. 2002 Mar;13(3):169-72
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory