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Cd22tm1Tft
Targeted Allele Detail
Nomenclature
Symbol: Cd22tm1Tft
Name: CD22 antigen; targeted mutation 1, Thomas F Tedder
MGI ID: MGI:2180700
Synonyms: CD22-
Gene: Cd22  Location: Chr7:30865404-30880342 bp, - strand  Genetic Position: Chr7, 19.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38051
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced a portion of the 5' untranslated region, the leader sequence, and a portion of the exon encoding the immunoglobulin (Ig) 1 domain. A stop codon was introduced into the 5' end of the exon encoding the Ig 1 domain. Immunohistochemical staining of frozen spleen sections, using various Ig-specific antibodies, showed a lack of secreted, cell surface, and cytoplasmic protein. The absence of sell surface expression was further confirmed by immunofluorescence staining of lymphocytes. (J:38051)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  38 strains or lines available
References
Original:  J:38051 Sato S, et al., CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity. 1996 Dec;5(6):551-62
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory