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Targeted Allele Detail
Symbol: Lcattm1Hgc
Name: lecithin cholesterol acyltransferase; targeted mutation 1, Edward M Rubin
MGI ID: MGI:2180695
Synonyms: Lcat (-), LCAT-
Gene: Lcat  Location: Chr8:105939551-105943382 bp, - strand  Genetic Position: Chr8, 53.06 cM
Plasma lipoprotein fractions of Lcattm1Hgc/Lcattm1Hgc mice contain smaller VLDL particles and complex HDL particles

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:41208
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a neomycin resistance cassette via homologous recombination. Exogenous substrate assay of plasma from homozygous mutant animals showed no detectable enzyme activity. (J:41208)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lcat Mutation:  5 strains or lines available
Original:  J:41208 Ng DS, et al., Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I. J Biol Chem. 1997 Jun 20;272(25):15777-81
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory