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Cd22tm1Eac
Targeted Allele Detail
Nomenclature
Symbol: Cd22tm1Eac
Name: CD22 antigen; targeted mutation 1, Edward A Clark
MGI ID: MGI:2180680
Synonyms: Cd22-
Gene: Cd22  Location: Chr7:30865402-30880342 bp, - strand  Genetic Position: Chr7, 19.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37451
Parent Cell Line:  E14.1a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPortions of exons 3 and 4 were replaced with a neomycin selection cassette, which introduced stop codons into all three reading frames. The deleted region encoded the translational start site, leader sequence, and the ligand-binding immunoglobulin domain 1. The splice sites on the 5' and 3' terminals of exons 3 and 4, respectively, were left intact. (J:37451)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  7 strains or lines available
References
Original:  J:37451 Otipoby KL, et al., CD22 regulates thymus-independent responses and the lifespan of B cells. Nature. 1996 Dec 19-26;384(6610):634-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory