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Targeted Allele Detail
Symbol: Cd22tm1Eac
Name: CD22 antigen; targeted mutation 1, Edward A Clark
MGI ID: MGI:2180680
Synonyms: Cd22-
Gene: Cd22  Location: Chr7:30865404-30880342 bp, - strand  Genetic Position: Chr7, 19.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:37451
Parent Cell Line:  E14.1a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPortions of exons 3 and 4 were replaced with a neomycin selection cassette, which introduced stop codons into all three reading frames. The deleted region encoded the translational start site, leader sequence, and the ligand-binding immunoglobulin domain 1. The splice sites on the 5' and 3' terminals of exons 3 and 4, respectively, were left intact. (J:37451)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  38 strains or lines available
Original:  J:37451 Otipoby KL, et al., CD22 regulates thymus-independent responses and the lifespan of B cells. Nature. 1996 Dec 19-26;384(6610):634-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory