Cd22^tm1Eac
Targeted Allele Detail

Summary

• Symbol: Cd22^tm1Eac
• Name: CD22 antigen; targeted mutation 1, Edward A Clark
• MGI ID: MGI:2180680
• Synonyms: Cd22^-
• Gene: Cd22 Location: Chr7:30564829-30579767 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Cd22^tm1Eac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37451
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 3 and 4 were replaced with a neomycin selection cassette, which introduced stop codons into all three reading frames. The deleted region encoded the translational start site, leader sequence, and the ligand-binding immunoglobulin domain 1. The splice sites on the 5' and 3' terminals of exons 3 and 4, respectively, were left intact. (J:37451)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd22 Mutation: 63 strains or lines available

References

• Original: J:37451 Otipoby KL, et al., CD22 regulates thymus-independent responses and the lifespan of B cells. Nature. 1996 Dec 19-26;384(6610):634-7
• All: 11 reference(s)