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Targeted Allele Detail
Symbol: Ccr7tm1Rfor
Name: chemokine (C-C motif) receptor 7; targeted mutation 1, Reinhold Forster
MGI ID: MGI:2180679
Synonyms: CCR7-
Gene: Ccr7  Location: Chr11:99144199-99155077 bp, - strand  Genetic Position: Chr11, 62.92 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:57976
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation details0.5 kb of exon 3 encoding serine 139 to aspartic acid 309 was disrupted by insertion of a neomycin resistance cassette via homologous recombination. Successful targeting was verified in homozygous mutant animals by Southern blot analysis and chemotaxis assays. Spleen cells from homozygous animals demonstrated lack of chemotactic response towards EBI-1 ligand chemokine (ELC), a known ligand of the targeted gene. (J:57976)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr7 Mutation:  15 strains or lines available
Original:  J:57976 Forster R, et al., CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999 Oct 1;99(1):23-33
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory