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Ctla4tm1All
Targeted Allele Detail
Nomenclature
Symbol: Ctla4tm1All
Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 1, James P Allison
MGI ID: MGI:2180670
Synonyms: CTLA-4-, CTLA-4 KO, Ctla4o, Ctla4o
Gene: Ctla4  Location: Chr1:60887000-60915832 bp, + strand  Genetic Position: Chr1, 30.58 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42481
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (knock-out)
Mutation:    Insertion
    The insertion of neomycin selection cassette under the control of a PGK promoter disrupted exon 3. (J:42481)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctla4 Mutation:  10 strains or lines available
References
Original:  J:42481 Chambers CA, et al., Thymocyte development is normal in CTLA-4-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9296-301
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory