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Targeted Allele Detail
Symbol: Cul1tmTye
Name: cullin 1; targeted mutation 1, Michael Tyers
MGI ID: MGI:2180659
Synonyms: Cul1-
Gene: Cul1  Location: Chr6:47453398-47526139 bp, + strand  Genetic Position: Chr6, 22.9 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:58150
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection gene replaced exon 2, which encodes the initiation codon and an essential binding site. Gene expression and Western blot analyses indicated that the targeted locus was null. (J:58150)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cul1 Mutation:  45 strains or lines available
Original:  J:58150 Wang Y, et al., Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Curr Biol. 1999 Oct 21;9(20):1191-4
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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