Ccna2^tm1Sot
Targeted Allele Detail

Summary

• Symbol: Ccna2^tm1Sot
• Name: cyclin A2; targeted mutation 1, Joelle Sobczak-Thepot
• MGI ID: MGI:2180634
• Synonyms: cyclin A2 (-)
• Gene: Ccna2 Location: Chr3:36619014-36626299 bp, - strand Genetic Position: Chr3, 17.67 cM
• Alliance: Ccna2^tm1Sot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37426
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a construct containing a lacZ gene with a nuclear localization signal linked to the 5' end and a neomycin gene under the control of thymidine kinase promoter. The endogenous promoter remained intact and controlled the expression of the inserted lacZ gene. Immunohistochemical analysis failed to detect cyclin A2 protein in morphologically abnormal embyros, which were presumed to be homozygous. (J:37426)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccna2 Mutation: 15 strains or lines available

References

• Original: J:37426 Murphy M, et al., Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat Genet. 1997 Jan;15(1):83-6
• All: 2 reference(s)