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Targeted Allele Detail
Symbol: Capn1tm1Ahc
Name: calpain 1; targeted mutation 1, Athar H Chishti
MGI ID: MGI:2180538
Synonyms: Capn-
Gene: Capn1  Location: Chr19:5988546-6015825 bp, - strand  Genetic Position: Chr19, 4.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:67798
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced the portion of exon 4 encoding amino acids 153 through 160, part of an essential catalytic domain. Expression analysis of homozygous mutant mice showed an absence of normal transcript and additionally that alternate trancripts were not produced by cryptic splicing. Western analysis revealed a lack of protein in homozygous mutants, while casein zymography did not detect calpain activity in platelets. (J:67798)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Capn1 Mutation:  15 strains or lines available
Original:  J:67798 Azam M, et al., Disruption of the mouse mu-calpain gene reveals an essential role in platelet function. Mol Cell Biol. 2001 Mar;21(6):2213-20
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory