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Il5ratm1Ktk
Targeted Allele Detail
Nomenclature
Symbol: Il5ratm1Ktk
Name: interleukin 5 receptor, alpha; targeted mutation 1, Kiyoshi Takatsu
MGI ID: MGI:2180501
Synonyms: IL-5Ralpha-
Gene: Il5ra  Location: Chr6:106710357-106749037 bp, - strand  Genetic Position: Chr6, 49.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33140
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA stop codon was introduced into exon 5 and a neo cassette was inserted into exon 6 via homologous recombination. The neo insertion disrupts 4 cysteine residues that are conserved within the cytokine receptor family. Absence of gene expression was verified by flow cytometry analysis of resting peritoneal cells from homozygous mutant animals. (J:33140)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il5ra Mutation:  15 strains or lines available
References
Original:  J:33140 Yoshida T, et al., Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity. 1996 May;4(5):483-94
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory