About   Help   FAQ
Il5ratm1Ktk
Targeted Allele Detail
Nomenclature
Symbol: Il5ratm1Ktk
Name: interleukin 5 receptor, alpha; targeted mutation 1, Kiyoshi Takatsu
MGI ID: MGI:2180501
Synonyms: IL-5Ralpha-
Gene: Il5ra  Location: Chr6:106710357-106749037 bp, - strand  Genetic Position: Chr6, 49.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33140
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA stop codon was introduced into exon 5 and a neo cassette was inserted into exon 6 via homologous recombination. The neo insertion disrupts 4 cysteine residues that are conserved within the cytokine receptor family. Absence of gene expression was verified by flow cytometry analysis of resting peritoneal cells from homozygous mutant animals. (J:33140)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il5ra Mutation:  20 strains or lines available
References
Original:  J:33140 Yoshida T, et al., Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity. 1996 May;4(5):483-94
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory