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Targeted Allele Detail
Symbol: Il5ratm1Ktk
Name: interleukin 5 receptor, alpha; targeted mutation 1, Kiyoshi Takatsu
MGI ID: MGI:2180501
Synonyms: IL-5Ralpha-
Gene: Il5ra  Location: Chr6:106687336-106725998 bp, - strand  Genetic Position: Chr6, 49.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:33140
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA stop codon was introduced into exon 5 and a neo cassette was inserted into exon 6 via homologous recombination. The neo insertion disrupts 4 cysteine residues that are conserved within the cytokine receptor family. Absence of gene expression was verified by flow cytometry analysis of resting peritoneal cells from homozygous mutant animals. (J:33140)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il5ra Mutation:  26 strains or lines available
Original:  J:33140 Yoshida T, et al., Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity. 1996 May;4(5):483-94
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory