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Selplgtm1Rpmc
Targeted Allele Detail
Nomenclature
Symbol: Selplgtm1Rpmc
Name: selectin, platelet (p-selectin) ligand; targeted mutation 1, Rodger P McEver
MGI ID: MGI:2180375
Synonyms: PSGL-1-
Gene: Selplg  Location: Chr5:113818536-113832644 bp, - strand  Genetic Position: Chr5, 55.59 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75829
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the 5' portion of exon 2, which includes the translation initiation start site, via homologous recombination. Flow cytometry was used to confirm the absence of gene expression in leukocytes of homozygous mutant animals. (J:75829, J:95268)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Selplg Mutation:  11 strains or lines available
References
Original:  J:75829 Xia L, et al., P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest. 2002 Apr;109(7):939-50
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory