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Atf4tm1Tow
Targeted Allele Detail
Nomenclature
Symbol: Atf4tm1Tow
Name: activating transcription factor 4; targeted mutation 1, Timothy Townes
MGI ID: MGI:2180373
Synonyms: Atf4-, Atf4 KO, Atf4tm1Tmt
Gene: Atf4  Location: Chr15:80255184-80257540 bp, + strand  Genetic Position: Chr15, 37.85 cM
Atf4tm1Tow/Atf4tm1Tow mice show pancreatic hypotrophy

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74479
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3, comprising the entire coding region, were replaced with a targeting construct containing a neomycin resistance gene. Expression analysis confirmed the absence of transcript in homozygous mutant mice. (J:74479)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atf4 Mutation:  13 strains or lines available
Notes
ES cell line = HM1 (129P2/OlaHsd-Hprtb-m3) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).

The data presented in J:74479 were obtained using R1 ES cells, though the authors report that they also generated mice with targeted alleles using HM1 ES cells.

References
Original:  J:74479 Masuoka HC, et al., Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 2002 Feb 1;99(3):736-45
All:  28 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory