Asah1tm1Esc
Targeted Allele Detail
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Symbol: |
Asah1tm1Esc |
Name: |
N-acylsphingosine amidohydrolase 1; targeted mutation 1, Edward H Schuchman |
MGI ID: |
MGI:2180367 |
Gene: |
Asah1 Location: Chr8:41340197-41374773 bp, - strand Genetic Position: Chr8, 23.89 cM
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Germline Transmission: |
Earliest citation of germline transmission:
J:74647
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Parent Cell Line: |
W9.5/W95 (ES Cell)
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Strain of Origin: |
129S1/Sv-Oca2+ Tyr+ Kitl+ |
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Constructs containing a PGK-neo cassette in place of exons 3 through 5 were inserted into ES cells. Southern blot and sequence analysis revealed that a single ES cell contained three constructs inserted into intron 12. This cell was to generate heterozygous mice.
(J:74647)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Asah1 Mutation: |
22 strains or lines available
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Original: |
J:74647 Li CM, et al., Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics. 2002 Feb;79(2):218-24 |
All: |
2 reference(s) |
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