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Targeted Allele Detail
Symbol: Cav1tm1Mls
Name: caveolin 1, caveolae protein; targeted mutation 1, Michael P Lisanti
MGI ID: MGI:2180364
Synonyms: cav-, Cav-1-, Cav-1 KO, Caveolin-1 KO, Cavtm1Mls
Gene: Cav1  Location: Chr6:17306335-17341328 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Cav1tm1Mls/Cav1tm1Mls mice show lung abnormalities, with thickened alveolar septa and hypercellularity

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:75193
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.2 kb region of the gene including exons 1 and 2 and part of the promoter region was replaced with a neo resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of heart, adipose, and lung tissue, and also of mouse embryonic fibroblasts cultured from E13.5 homozygous mutant embryos. (J:75193)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 45 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:  23 strains or lines available
Original:  J:75193 Razani B, et al., Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001 Oct 12;276(41):38121-38
All:  200 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory