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Cav1tm1Mls
Targeted Allele Detail
Nomenclature
Symbol: Cav1tm1Mls
Name: caveolin 1, caveolae protein; targeted mutation 1, Michael P Lisanti
MGI ID: MGI:2180364
Synonyms: cav-, Cav-1-, Cav-1 KO, Caveolin-1 KO, Cavtm1Mls
Gene: Cav1  Location: Chr6:17306335-17341452 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Cav1tm1Mls/Cav1tm1Mls mice show lung abnormalities, with thickened alveolar septa and hypercellularity

Show the 4 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75193
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:  3 strains or lines available
References
Original:  J:75193 Razani B, et al., Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001 Oct 12;276(41):38121-38
All:  137 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory