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Targeted Allele Detail
Symbol: Arsatm1Gie
Name: arylsulfatase A; targeted mutation 1, Volkmar Gieselmann
MGI ID: MGI:2180363
Synonyms: As2-, ASA(-)
Gene: Arsa  Location: Chr15:89472476-89477425 bp, - strand  Genetic Position: Chr15, 44.94 cM, cytoband E
Histochemistry and ultrastructure of sulfatide storage in the brain of Arsatm1Gie/Arsatm1Gie mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:37978
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was inserted into exon 4, disrupting the open reading frame. Complete absence of enzyme activity was confirmed by Northern blot analysis and by the sulfatide loading assay. (J:37978)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arsa Mutation:  1 strain or line available
Original:  J:37978 Hess B, et al., Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14821-6
All:  24 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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