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Targeted Allele Detail
Symbol: Arntltm1Bra
Name: aryl hydrocarbon receptor nuclear translocator-like; targeted mutation 1, Christopher A Bradfield
MGI ID: MGI:2180361
Synonyms: bmal1-, Bmal1-KO, mMop3-, Mop3-
Gene: Arntl  Location: Chr7:113207465-113314126 bp, + strand  Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
Joint abnormalities with ectopic ossification in Arntltm1Bra/Arntltm1Bra mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:66502
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 4 containing the helix-loop-helix coding domain and all of exon 5 were replaced by a neomycin selection cassette. A larger transcript, resulting from a cryptic splice site between exon 3 and the neomycin resistance gene, was detected by Northern blot analysis. The polypeptide truncates 15 residues after this splice site, prior to the functional domains encoded by exon 4 in the wild-type locus. (J:66502)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 37 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arntl Mutation:  125 strains or lines available
Original:  J:66502 Bunger MK, et al., Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 2000 Dec 22;103(7):1009-17
All:  119 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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