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Itpr1tm1Tno
Targeted Allele Detail
Summary
Symbol: Itpr1tm1Tno
Name: inositol 1,4,5-trisphosphate receptor 1; targeted mutation 1, Tetsuo Noda
MGI ID: MGI:2180360
Synonyms: InsP3R1-, IP3R1-
Gene: Itpr1  Location: Chr6:108190057-108528070 bp, + strand  Genetic Position: Chr6, 49.74 cM
Alliance: Itpr1tm1Tno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30633
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the first coding exon of the gene which contains 5' untranslated sequence and the sequence for the first 31 amino acids. A lack of protein from the cerebellum of homozygous mutant animals was demonstrated by Western analysis. Additional binding studies and Ca2+ release assays were incorporated to demonstrate the loss of function for this allele. (J:30633)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itpr1 Mutation:  180 strains or lines available
References
Original:  J:30633 Matsumoto M, et al., Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature. 1996 Jan 11;379(6561):168-71
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory