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Targeted Allele Detail
Symbol: Phox2atm1Jbr
Name: paired-like homeobox 2a; targeted mutation 1, Jean-Francois Brunet
MGI ID: MGI:2180328
Synonyms: Phox2a-
Gene: Phox2a  Location: Chr7:101818313-101822726 bp, + strand  Genetic Position: Chr7, 54.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:39084
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette was used to delete a portion of exon 2 and all of exon 3, eliminating the sequences encoding the homeodomain and all downstream sequence. The truncated message was believed to be unstable due to the absence of a signal in Northern blot analysis. (J:39084)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2a Mutation:  8 strains or lines available
Original:  J:39084 Morin X, et al., Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron. 1997 Mar;18(3):411-23
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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