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Defb1tm1Jmw
Targeted Allele Detail
Nomenclature
Symbol: Defb1tm1Jmw
Name: defensin beta 1; targeted mutation 1, James M Wilson
MGI ID: MGI:2180305
Synonyms: mBD-1-
Gene: Defb1  Location: Chr8:21776599-21795185 bp, + strand  Genetic Position: Chr8, 10.35 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76529
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin resistance gene via homologous recombination. Gene expression is absent in kidneys and trachea of homozygous mutant animals as determined by Northern blot analysis, RNase protection assay, and RT-PCR. (J:76529)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Defb1 Mutation:  0 strains or lines available
References
Original:  J:76529 Moser C, et al., beta-Defensin 1 contributes to pulmonary innate immunity in mice. Infect Immun. 2002 Jun;70(6):3068-72
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory