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Sgcdtm1Mcn
Targeted Allele Detail
Nomenclature
Symbol: Sgcdtm1Mcn
Name: sarcoglycan, delta (dystrophin-associated glycoprotein); targeted mutation 1, Elizabeth M McNally
MGI ID: MGI:2180193
Synonyms: dsg-, Scgd-
Gene: Sgcd  Location: Chr11:46896253-47988969 bp, - strand  Genetic Position: Chr11, 28.09 cM, cytoband B1.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76730
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette was used to replace exon 2, which encodes the translation initiation codon and the cytoplasmic and transmembrane domains. Northern analysis showed that message was not transcribed in skeletal muscle of homozygous mutant mice. The lack of protein in immunoblots further confirmed complete inactivation. (J:76730)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sgcd Mutation:  7 strains or lines available
References
Original:  J:76730 Hack AA, et al., Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex. J Cell Sci. 2000 Jul;113(Pt 14):2535-44
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory