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Targeted Allele Detail
Symbol: Scn10atm1Jnw
Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 1, John N Wood
MGI ID: MGI:2180183
Synonyms: Nav1.8-, SNS-
Gene: Scn10a  Location: Chr9:119608456-119719322 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Germline Transmission:  Earliest citation of germline transmission: J:76456
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 4 and all of exon 5, which encodes the S4 voltage sensor of domain I, were replaced with a PGK-neo cassette via homologous recombination. The PGK-neo cassette introduces stop codons in all 3 reading frames. RT-PCR analysis detected weak expression of mutant transcripts in homozygous mutant animals. (J:76456)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:  57 strains or lines available
Original:  J:76456 Akopian AN, et al., The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci. 1999 Jun;2(6):541-8
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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