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Snap25tm1Mcw
Targeted Allele Detail
Nomenclature
Symbol: Snap25tm1Mcw
Name: synaptosomal-associated protein 25; targeted mutation 1, Michael C Wilson
MGI ID: MGI:2180178
Synonyms: Snap25-
Gene: Snap25  Location: Chr2:136713453-136782428 bp, + strand  Genetic Position: Chr2, 67.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73755
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5a/b and part of the downstream intron were replaced with a PGK-neo cassette by homologous recombination. Western blot of brain proteins and RT-PCR analysis of total brain RNA from homozygous mutant embryos verified the absence of gene expression. (J:73755)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Snap25 Mutation:  19 strains or lines available
References
Original:  J:73755 Washbourne P, et al., Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. Nat Neurosci. 2002 Jan;5(1):19-26
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory