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Ap1m1tm1Schu
Targeted Allele Detail
Nomenclature
Symbol: Ap1m1tm1Schu
Name: adaptor-related protein complex AP-1, mu subunit 1; targeted mutation 1, Peter Schu
MGI ID: MGI:2180171
Synonyms: delta-mu-1
Gene: Ap1m1  Location: Chr8:72240018-72257385 bp, + strand  Genetic Position: Chr8, 34.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62184
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted to disrupt an exon of the mu-adaptin gene. Northern analysis of total RNA isolated from homozygous embryos revealed an absence of transcript. Western analysis of homozygous mutants showed a 30% reduction in gamma-adaptin and a 70% reduction in sigma1-adaptin relative to a control. (J:62184)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ap1m1 Mutation:  10 strains or lines available
References
Original:  J:62184 Meyer C, et al., mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 2000 May 15;19(10):2193-203
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory