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Targeted Allele Detail
Symbol: Cacna1etm1Rjml
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1, Richard J Miller
MGI ID: MGI:2180170
Gene: Cacna1e  Location: Chr1:154390731-154884501 bp, - strand  Genetic Position: Chr1, 66.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:66144
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4-8 encoding the pore-lining domain and neighboring transmembrane domains were replaced with a neo-URA3 cassette via homologous recombination. Western blot of brain extract from homozygous mutant animals confirmed the absence of protein product. Northern blot analysis also failed to detect gene expression. (J:66144)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1e Mutation:  55 strains or lines available
Original:  J:66144 Wilson SM, et al., The status of voltage-dependent calcium channels in alpha 1E knock-Out mice. J Neurosci. 2000 Dec 1;20(23):8566-71
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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