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Targeted Allele Detail
Symbol: Ambptm1Miya
Name: alpha 1 microglobulin/bikunin; targeted mutation 1, Jun-ichi Miyazaki
MGI ID: MGI:2180160
Synonyms: UTI-
Gene: Ambp  Location: Chr4:63143275-63154799 bp, - strand  Genetic Position: Chr4, 33.96 cM, cytoband C1-C3
Germline Transmission:  Earliest citation of germline transmission: J:68118
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a portion of exon 8, all of exon 9, and a portion of exon 10. The deleted region encodes the Kunitz domains that impart serine proteinase inhibitor activity in bikunin. Western blot analysis of plasma from homozygous mutant mice showed an absence of the two forms of the encoded protein (220kDa and 120kDa) that were present in wild-type mice. (J:68118)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ambp Mutation:  16 strains or lines available
Original:  J:68118 Sato H, et al., Impaired fertility in female mice lacking urinary trypsin inhibitor. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1154-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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