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Targeted Allele Detail
Symbol: Syt4tm1Hahe
Name: synaptotagmin IV; targeted mutation 1, Harvey R Herschman
MGI ID: MGI:2180158
Synonyms: Syt4tm1Hrh, Syt IV -/-
Gene: Syt4  Location: Chr18:31437808-31447406 bp, - strand  Genetic Position: Chr18, 17.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:62218
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a neo resistance cassette into an exon encoding the first C2 domain. Northern blot of total brain RNA from homozygous mutant animals verified the absence of gene expression. (J:62218)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syt4 Mutation:  14 strains or lines available
Original:  J:62218 Ferguson GD, et al., Deficits in memory and motor performance in synaptotagmin IV mutant mice. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5598-603
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory