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Cacng1tm1Vfz
Targeted Allele Detail
Nomenclature
Symbol: Cacng1tm1Vfz
Name: calcium channel, voltage-dependent, gamma subunit 1; targeted mutation 1, Veit Flockerzi
MGI ID: MGI:2180153
Synonyms: gamma-, gamma1-
Gene: Cacng1  Location: Chr11:107703218-107716522 bp, - strand  Genetic Position: Chr11, 70.29 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62133
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3' portion of exon 1 and adjacent splice donor site were replaced with a neo resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis of skeletal muscle from homozygous mutant animals. In addition, RT-PCR failed to amplify the complete coding region of the gene as well as portions of the transcript corresponding to exons 2, 3, and 4. (J:62133)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacng1 Mutation:  6 strains or lines available
References
Original:  J:62133 Freise D, et al., Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties. J Biol Chem. 2000 May 12;275(19):14476-81
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory