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Targeted Allele Detail
Symbol: Akt1tm1Mbb
Name: thymoma viral proto-oncogene 1; targeted mutation 1, Morris J Birnbaum
MGI ID: MGI:2180150
Synonyms: Akt-
Gene: Akt1  Location: Chr12:112653821-112674884 bp, - strand  Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:72176
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene was used to replace exons 4 through 7 and the 5' portion of exon 8. Exon 5 is known to encode an lysine residue essential for catalytic activity. Expression was undetected in homozygous mutant animals by both Northern and Western blot analyses. The authors noted that the expression of Akt2 and Akt3 was normal in mice homozygous for the targeted allele. (J:72176)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akt1 Mutation:  22 strains or lines available
Original:  J:72176 Cho H, et al., Akt1/pkbalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem. 2001 Oct 19;276(42):38349-52
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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