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Targeted Allele Detail
Symbol: Pex2tm1Plf
Name: peroxisomal biogenesis factor 2; targeted mutation 1, Phyllis L Faust
MGI ID: MGI:2180128
Synonyms: PEX2-
Gene: Pex2  Location: Chr3:5560499-5576239 bp, - strand  Genetic Position: Chr3, 1.96 cM
Variable size of and cranial abnormalities in Pex2tm1Plf/Pex2tm1Plf mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:44975
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PKC-neo cassette was used to replace exon 5, which contains the translation initiation site and the entire coding sequence. Northern analysis of RNA isolated from the liver, brain, and kidney of homozygous mutant mice revealed an absence of message. (J:44975)
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pex2 Mutation:  9 strains or lines available
Original:  J:44975 Faust PL, et al., Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder. J Cell Biol. 1997 Dec 1;139(5):1293-305
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory