Nefh^tm1Jpj
Targeted Allele Detail

Summary

• Symbol: Nefh^tm1Jpj
• Name: neurofilament, heavy polypeptide; targeted mutation 1, Jean-Pierre Julien
• MGI ID: MGI:2180125
• Synonyms: NF-H-
• Gene: Nefh Location: Chr11:4888754-4898064 bp, - strand Genetic Position: Chr11, 3.12 cM, cytoband A1-A5
• Alliance: Nefh^tm1Jpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55453
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neo resistance cassette via homologous recombination. No mRNA or protein was detected in brain of homozygous mutant animals via Northern and Western blot analysis. (J:55453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nefh Mutation: 48 strains or lines available

References

• Original: J:55453 Zhu Q, et al., Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile [see comments]. J Cell Biol. 1998 Oct 5;143(1):183-93
• All: 7 reference(s)