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Targeted Allele Detail
Symbol: Pzptm1Vln
Name: PZP, alpha-2-macroglobulin like; targeted mutation 1, Fred Van Leuven
MGI ID: MGI:2180117
Synonyms: MAM-
Gene: Pzp  Location: Chr6:128460530-128503683 bp, - strand  Genetic Position: Chr6, 63.02 cM, cytoband F1-G3
Alliance: Pzptm1Vln page
Germline Transmission:  Earliest citation of germline transmission: J:28328
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA construct was created by replacing 0.7-kb of intron 17 with PKC-hygro. Northern analysis of RNA isolated from the livers of homozygous mice showed an absence of transcript. Rocket immunoelectrophoresis also showed no expression. (J:28328)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 62 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pzp Mutation:  56 strains or lines available
Original:  J:28328 Umans L, et al., Targeted inactivation of the mouse alpha 2-macroglobulin gene. J Biol Chem. 1995 Aug 25;270(34):19778-85
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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