About   Help   FAQ
Tlx3tm1Sjk
Targeted Allele Detail
Summary
Symbol: Tlx3tm1Sjk
Name: T cell leukemia, homeobox 3; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:2180105
Synonyms: Rnx-, Tlx3-
Gene: Tlx3  Location: Chr11:33150752-33153589 bp, - strand  Genetic Position: Chr11, 19.21 cM, cytoband A5
Alliance: Tlx3tm1Sjk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60751
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette was inserted into exon 1. RNA in situ analysis confirmed the lack of gene expression in homozygous mice. (J:60751)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 22 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx3 Mutation:  14 strains or lines available
References
Original:  J:60751 Shirasawa S, et al., Rnx deficiency results in congenital central hypoventilation. Nat Genet. 2000 Mar;24(3):287-90
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/09/2024
MGI 6.23
The Jackson Laboratory