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Tlx3tm1Sjk
Targeted Allele Detail
Nomenclature
Symbol: Tlx3tm1Sjk
Name: T cell leukemia, homeobox 3; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:2180105
Synonyms: Rnx-, Tlx3-
Gene: Tlx3  Location: Chr11:33200752-33203589 bp, - strand  Genetic Position: Chr11, 19.21 cM, cytoband A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60751
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette was inserted into exon 1. RNA in situ analysis confirmed the lack of gene expression in homozygous mice. (J:60751)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx3 Mutation:  4 strains or lines available
References
Original:  J:60751 Shirasawa S, et al., Rnx deficiency results in congenital central hypoventilation. Nat Genet. 2000 Mar;24(3):287-90
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory