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Targeted Allele Detail
Symbol: Adh1tm1Gdu
Name: alcohol dehydrogenase 1 (class I); targeted mutation 1, Gregg Duester
MGI ID: MGI:2180100
Synonyms: Adh1-
Gene: Adh1  Location: Chr3:138260991-138290698 bp, + strand  Genetic Position: Chr3, 64.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:55555
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExons 7 through 9 were replaced with a PGK-neo gene downstream of exon 6. Transcripts were undetectable in total RNA extracts from the liver, kidney, and epididymis of homozygous mice by Northern analysis. A lack of protein expression was confirmed by Western blot analysis. (J:55555)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adh1 Mutation:  14 strains or lines available
Original:  J:55555 Deltour L, et al., Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem. 1999 Jun 11;274(24):16796-801
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory