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Targeted Allele Detail
Symbol: Adh1tm2Gdu
Name: alcohol dehydrogenase 1 (class I); targeted mutation 2, Gregg Duester
MGI ID: MGI:2180099
Synonyms: Adh1-
Gene: Adh1  Location: Chr3:138277585-138290698 bp, + strand  Genetic Position: Chr3, 64.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:76055
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 7 through 9 and the polyadenylation signal were replaced with a PGK-hygro gene downstream of exon 6. This construct was developed by altering a previously described construct, tm1Due, containing a neomycin selection gene, for use in the generation of a double knockout. (J:76055)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adh1 Mutation:  2 strains or lines available
A modified R1 ES cell line dervived from (129X1/SvJ x 129S1/Sv)F1-Kitl+ containing a targeted Adh3 (class III) locus was used.
Original:  J:76055 Molotkov A, et al., Distinct Retinoid Metabolic Functions for Alcohol Dehydrogenase Genes Adh1 and Adh4 in Protection against Vitamin A Toxicity or Deficiency Revealed in Double Null Mutant Mice. J Biol Chem. 2002 Apr 19;277(16):13804-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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