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Targeted Allele Detail
Symbol: Nefltm1Jpj
Name: neurofilament, light polypeptide; targeted mutation 1, Jean-Pierre Julien
MGI ID: MGI:2180095
Synonyms: L-, NF-L-, NFL-
Gene: Nefl  Location: Chr14:68083863-68089095 bp, + strand  Genetic Position: Chr14, 35.46 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:44421
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details0.7 kb of the gene including exon 1 was replaced with a neomycin resistance cassette by homologous recombination. Northern and Western blots of brain and nervous tissue from homozygous mutant animals did not detect gene expression, nor were any truncated mRNA species or protein fragments detected. (J:44421)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nefl Mutation:  3 strains or lines available
Original:  J:44421 Zhu Q, et al., Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp Neurol. 1997 Nov;148(1):299-316
All:  29 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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