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Targeted Allele Detail
Symbol: Sh2b3tm1Rmp
Name: SH2B adaptor protein 3; targeted mutation 1, Roger M Perlmutter
MGI ID: MGI:2180088
Synonyms: lnk-
Gene: Sh2b3  Location: Chr5:121953551-121975709 bp, - strand  Genetic Position: Chr5, 61.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:66032
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of the coding region was replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis verified the absence of gene expression in homozygous mutant animals. (J:66032)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh2b3 Mutation:  17 strains or lines available
Original:  J:66032 Takaki S, et al., Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity. 2000 Nov;13(5):599-609
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory