Sh2b3^tm1Rmp
Targeted Allele Detail

Summary

• Symbol: Sh2b3^tm1Rmp
• Name: SH2B adaptor protein 3; targeted mutation 1, Roger M Perlmutter
• MGI ID: MGI:2180088
• Synonyms: lnk-
• Gene: Sh2b3 Location: Chr5:121953551-121975709 bp, - strand Genetic Position: Chr5, 61.99 cM
• Alliance: Sh2b3^tm1Rmp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66032
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region was replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis verified the absence of gene expression in homozygous mutant animals. (J:66032)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh2b3 Mutation: 22 strains or lines available

References

• Original: J:66032 Takaki S, et al., Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity. 2000 Nov;13(5):599-609
• All: 21 reference(s)