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Acp5tm1Ahdm
Targeted Allele Detail
Nomenclature
Symbol: Acp5tm1Ahdm
Name: acid phosphatase 5, tartrate resistant; targeted mutation 1, Addenbrookes Hospital Department of Medicine
MGI ID: MGI:2180086
Synonyms: Acp5-, TRACP-, TRAP-
Gene: Acp5  Location: Chr9:22126731-22135746 bp, - strand  Genetic Position: Chr9, 8.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36232
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2, which encodes the conserved putative iron-binding domain, was disrupted by the insertion of a neomycin resistance gene. Acid phosphatase activity specific to this osteoclast isozyme was assayed and found to be undetectable in bone homogenates from homozygous mutant mice. Further analysis using histochemical staining confirmed the absence of a functional enzyme. (J:36232)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acp5 Mutation:  9 strains or lines available
References
Original:  J:36232 Hayman AR, et al., Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development. 1996 Oct;122(10):3151-62
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory