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Dnah5Tg1Htz
Transgenic Allele Detail
Nomenclature
Symbol: Dnah5Tg1Htz
Name: dynein, axonemal, heavy chain 5; transgene insertion 1, Nathaniel Heintz
MGI ID: MGI:2180081
Synonyms: Mdnah5 -
Gene: Dnah5  Location: Chr15:28203752-28472045 bp, + strand  Genetic Position: Chr15, 10.9 cM
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA/J)F1
Transgene
description
Transgene Type:    Transgenic
Mutation:    Insertion
 
Mutation detailsThis mutation resulted from the random integration of a transgene (not identified in paper). RT-PCR analysis demonstrated that a transcript with the transgene replacing sequences between exons 16 and 22 was expressed, resulting in the generation of a stop codon at the start of the transgene. The predicted translated product of this fusion transcript lacks all of the known functional domains of the protein. (J:76189)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnah5 Mutation:  12 strains or lines available
References
Original:  J:76189 Ibanez-Tallon I, et al., Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus. Hum Mol Genet. 2002 Mar 15;11(6):715-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory