About   Help   FAQ
Abcb1atm1Bor
Targeted Allele Detail
Nomenclature
Symbol: Abcb1atm1Bor
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A; targeted mutation 1, Piet Borst
MGI ID: MGI:2180054
Synonyms: mdr1a-
Gene: Abcb1a  Location: Chr5:8660077-8748575 bp, + strand  Genetic Position: Chr5, 3.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18554
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.6-kb fragment containing exons 6 and 7 and encoding the extracellular, transmembrane, and cytoplasmic domains, was replaced by the insertion of a hygromycin cassette. While low levels of transcript were detected in the intestines of homozygous mutant mice by RNAase protection assays, immunoblot analysis showed an absence of protein expression. (J:18554)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Abcb1a Mutation:  39 strains or lines available
References
Original:  J:18554 Schinkel AH, et al., Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 1994 May 20;77(4):491-502
All:  85 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory