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Zmpste24tm1Otin
Targeted Allele Detail
Nomenclature
Symbol: Zmpste24tm1Otin
Name: zinc metallopeptidase, STE24; targeted mutation 1, Carlos Lopez-Otin
MGI ID: MGI:2180033
Synonyms: Zmpste24tm1Lotn
Gene: Zmpste24  Location: Chr4:120916434-120955438 bp, - strand  Genetic Position: Chr4, 56.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76209
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/Ola
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a promoter-less IRES-beta-geo cassette via homologous recombination. Western blot analysis of kidneys from homozygous mutant animals confirmed absence of gene expression. (J:76209)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zmpste24 Mutation:  25 strains or lines available
References
Original:  J:76209 Pendas AM, et al., Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet. 2002 May;31(1):94-9
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory