Zmpste24^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Zmpste24^tm1Otin
• Name: zinc metallopeptidase, STE24; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:2180033
• Synonyms: Zmpste24^tm1Lotn
• Gene: Zmpste24 Location: Chr4:120916434-120955438 bp, - strand Genetic Position: Chr4, 56.8 cM
• Alliance: Zmpste24^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/Ola

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a promoter-less IRES-beta-geo cassette via homologous recombination. Western blot analysis of kidneys from homozygous mutant animals confirmed absence of gene expression. (J:76209)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zmpste24 Mutation: 32 strains or lines available

References

• Original: J:76209 Pendas AM, et al., Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet. 2002 May;31(1):94-9
• All: 22 reference(s)