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Kcnj8tm1Sse
Targeted Allele Detail
Nomenclature
Symbol: Kcnj8tm1Sse
Name: potassium inwardly-rectifying channel, subfamily J, member 8; targeted mutation 1, Susumu Seino
MGI ID: MGI:2180015
Synonyms: Kir6.1-null
Gene: Kcnj8  Location: Chr6:142564837-142571614 bp, - strand  Genetic Position: Chr6, 74.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76195
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of intron 2 and exon 3, which encode the pore-forming region of the ion channel, were replaced with a neomycin resistance cassette via homologous recombination. Lack of gene expression in brain, heart, and liver of homozygous mutant animals was confirmed via Northern blot analysis. (J:76195)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnj8 Mutation:  4 strains or lines available
References
Original:  J:76195 Miki T, et al., Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med. 2002 May;8(5):466-72
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory