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Lcp2tm1Gak
Targeted Allele Detail
Nomenclature
Symbol: Lcp2tm1Gak
Name: lymphocyte cytosolic protein 2; targeted mutation 1, Gary A Koretzky
MGI ID: MGI:2180002
Synonyms: SLP-76-
Gene: Lcp2  Location: Chr11:34046928-34092281 bp, + strand  Genetic Position: Chr11, 19.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76697
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately 360 bp of the gene, including part of exon 1 and the translation initiation site, was replaced with a neo cassette via homologous recombination. RT-PCR analysis of homozygous mutant animals verified the absence of gene expression. Western blot and immunohistochemistry of spleen from homozygous mutant animals did not detect protein product. (J:76697)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lcp2 Mutation:  5 strains or lines available
References
Original:  J:76697 Clements JL, et al., Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science. 1998 Jul 17;281(5375):416-9
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory