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Targeted Allele Detail
Symbol: Arhgap5tm1Jset
Name: Rho GTPase activating protein 5; targeted mutation 1, Jeffrey Settleman
MGI ID: MGI:2179998
Synonyms: p190 B RhoGAP-
Gene: Arhgap5  Location: Chr12:52503972-52571975 bp, + strand  Genetic Position: Chr12, 22.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:76484
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA PGK-neo cassette is inserted in reverse transcriptional orientation relative to the coding sequence, disrupting the gene immediately upstream of the GTPase domain. Immunoblot of embryonic tissue probed with antisera failed to detect protein in homozygous mutant animals. (J:76484)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgap5 Mutation:  29 strains or lines available
Original:  J:76484 Sordella R, et al., Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development. Dev Cell. 2002 May;2(5):553-65
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory