About   Help   FAQ
Arhgap5tm1Jset
Targeted Allele Detail
Nomenclature
Symbol: Arhgap5tm1Jset
Name: Rho GTPase activating protein 5; targeted mutation 1, Jeffrey Settleman
MGI ID: MGI:2179998
Synonyms: p190 B RhoGAP-
Gene: Arhgap5  Location: Chr12:52503972-52571975 bp, + strand  Genetic Position: Chr12, 22.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76484
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neo cassette is inserted in reverse transcriptional orientation relative to the coding sequence, disrupting the gene immediately upstream of the GTPase domain. Immunoblot of embryonic tissue probed with antisera failed to detect protein in homozygous mutant animals. (J:76484)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgap5 Mutation:  29 strains or lines available
References
Original:  J:76484 Sordella R, et al., Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development. Dev Cell. 2002 May;2(5):553-65
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/11/2020
MGI 6.14
The Jackson Laboratory