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Tg(tetO-Kras2)12Hev
Transgene Detail
Nomenclature
Symbol: Tg(tetO-Kras2)12Hev
Name: transgene insertion 12, Harold E Varmus
MGI ID: MGI:2179992
Synonyms: KE, K-ras4bG12D, K-Ras4bG12D responder, K-Ras4bG12D responder, K-rasG12D-5, TetO-KrasG12D, Tet-op-K-ras, Tet-op-K-RasG12D, TOR, tre-Kras, TRE-KrasG12D
Transgene: Tg(tetO-Kras2)12Hev  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-Kras2)12Hev expresses 1 gene
 
Mutation detailsThe transgene expresses the mutant gene Kras4bG12D, under the control of a tetracycline-responsive promoter element (tTA), mp-1 intron polyadenylation site sequence, and a minimal CMV promoter. (J:73468)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Homozygous transgenic mice are viable and fertile. In conjunction with a second transgene encoding either rtTA (reverse tetracycline trans-activator protein) or tTA (the tetracycline trans-activator), mice carrying Tg(tetO-Kras2)12Hev show tissue-specific expression of the mutated K-ras transgene that may be induced or suppressed by administration of the tetracycline analog, doxycycline. Cessation or initiation of doxycycline treatment in bitransgenic strains containing, respectively, rtTA or tTA, will result in a rapid decrease of expression of the transgene.
References
Original:  J:73468 Fisher GH, et al., Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 2001 Dec 15;15(24):3249-62
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/08/2020
MGI 6.15
The Jackson Laboratory