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Ckmtm1Bew
Targeted Allele Detail
Summary
Symbol: Ckmtm1Bew
Name: creatine kinase, muscle; targeted mutation 1, Be Wieringa
MGI ID: MGI:2179990
Synonyms: M-CK-, MM-CK-, MMKO
Gene: Ckm  Location: Chr7:19145019-19155508 bp, + strand  Genetic Position: Chr7, 9.67 cM
Alliance: Ckmtm1Bew page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76699
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.9 kb region encompassing exon 2 and part of introns 1 and 2 was replaced with a hygroB resistance cassette via homologous recombination. Northern blot using an exon 2 probe demonstrated lack of gene transcripts in skeletal muscle and staining for enzyme activity was negative in homogenates of skeletal and cardiac muscle from homozygous mutant animals. (J:76699)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ckm Mutation:  38 strains or lines available
References
Original:  J:76699 van Deursen J, et al., Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell. 1993 Aug 27;74(4):621-31
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory