Ckmtm1Bew
Targeted Allele Detail
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Symbol: |
Ckmtm1Bew |
Name: |
creatine kinase, muscle; targeted mutation 1, Be Wieringa |
MGI ID: |
MGI:2179990 |
Synonyms: |
M-CK-, MM-CK-, MMKO |
Gene: |
Ckm Location: Chr7:19145019-19155508 bp, + strand Genetic Position: Chr7, 9.67 cM
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Alliance: |
Ckmtm1Bew page
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Germline Transmission: |
Earliest citation of germline transmission:
J:76699
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 0.9 kb region encompassing exon 2 and part of introns 1 and 2 was replaced with a hygroB resistance cassette via homologous recombination. Northern blot using an exon 2 probe demonstrated lack of gene transcripts in skeletal muscle and staining for enzyme activity was negative in homogenates of skeletal and cardiac muscle from homozygous mutant animals.
(J:76699)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ckm Mutation: |
38 strains or lines available
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Original: |
J:76699 van Deursen J, et al., Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell. 1993 Aug 27;74(4):621-31 |
All: |
34 reference(s) |
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