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Maktm1Yshk
Targeted Allele Detail
Summary
Symbol: Maktm1Yshk
Name: male germ cell-associated kinase; targeted mutation 1, Yoichi Shinkai
MGI ID: MGI:2179972
Synonyms: Mak-
Gene: Mak  Location: Chr13:41178484-41233182 bp, - strand  Genetic Position: Chr13, 20.25 cM
Alliance: Maktm1Yshk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76245
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 5-8 were replaced with a neo cassette via homologous recombination resulting in deletion of 45% of the protein product including a kinase domain and PQ-rich domain. Western blot of testicular samples from homozygous mutant animals verified the absence of protein and enzyme assays were negative for kinase activity. (J:76245)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mak Mutation:  22 strains or lines available
References
Original:  J:76245 Shinkai Y, et al., A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation. Mol Cell Biol. 2002 May;22(10):3276-80
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory