About   Help   FAQ
Targeted Allele Detail
Symbol: Maktm1Yshk
Name: male germ cell-associated kinase; targeted mutation 1, Yoichi Shinkai
MGI ID: MGI:2179972
Synonyms: Mak-
Gene: Mak  Location: Chr13:41178484-41233182 bp, - strand  Genetic Position: Chr13, 20.25 cM
Alliance: Maktm1Yshk page
Germline Transmission:  Earliest citation of germline transmission: J:76245
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 5-8 were replaced with a neo cassette via homologous recombination resulting in deletion of 45% of the protein product including a kinase domain and PQ-rich domain. Western blot of testicular samples from homozygous mutant animals verified the absence of protein and enzyme assays were negative for kinase activity. (J:76245)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mak Mutation:  22 strains or lines available
Original:  J:76245 Shinkai Y, et al., A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation. Mol Cell Biol. 2002 May;22(10):3276-80
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory