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Targeted Allele Detail
Symbol: Achetm1Loc
Name: acetylcholinesterase; targeted mutation 1, Oksana Lockridge
MGI ID: MGI:2179948
Synonyms: AChE-, AChE ko
Gene: Ache  Location: Chr5:137288247-137294466 bp, + strand  Genetic Position: Chr5, 76.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:56242
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 5 kb genomic fragment containing exons 2-5 was replaced by a neomycin resistance gene cassette. Enzymatic activity assays on blood serum derived from homozygous mice confirmed that no functional protein was made from this allele. (J:56242)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ache Mutation:  16 strains or lines available
Original:  J:56242 Xie W, et al., Knockout of one acetylcholinesterase allele in the mouse. Chem Biol Interact. 1999 May 14;119-120:289-99
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory